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Decason 0.5mg Tablet 1 Strip
Dexamethasone suppresses inflammation by preventing leukocyte migration and reversing increased capillary permeability. It also suppresses immune system activity.
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✅ Description:
Dexamethasone is a synthetic glucocorticoid used in the management of severe allergic conditions, inflammatory disorders, and various other medical conditions, including:
- Allergic Conditions: Severe cases of asthma, atopic/contact dermatitis, drug hypersensitivity, rhinitis, and serum sickness unresponsive to conventional treatments.
- Collagen Disorders: Lupus erythematosus, rheumatoid arthritis, and related conditions.
- Dermatologic Diseases: Severe forms of erythema multiforme (Stevens-Johnson syndrome), pemphigus, mycosis fungoides, bullous dermatitis herpetiformis, and exfoliative erythroderma.
- Endocrine Disorders: Primary/secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia linked to cancer, and nonsuppurative thyroiditis.
- Gastrointestinal Diseases: Ulcerative colitis and regional enteritis.
- Hematologic Disorders: Conditions like idiopathic thrombocytopenic purpura in adults, autoimmune hemolytic anemia, and Diamond-Blackfan anemia.
- Neoplastic Diseases: Treatment of leukemias and lymphomas.
- Neurological Disorders: Used in acute multiple sclerosis exacerbations, cerebral edema related to tumors, head injury, or craniotomy.
- Ophthalmic Diseases: Uveitis, temporal arteritis, and inflammatory eye conditions resistant to topical corticosteroids.
- Renal Disorders: Management of idiopathic nephrotic syndrome and lupus-induced proteinuria.
- Respiratory Diseases: Treatment of sarcoidosis, pulmonary tuberculosis (alongside antituberculous drugs), eosinophilic pneumonia, and berylliosis.
- Rheumatic Disorders: Short-term therapy in psoriatic arthritis, ankylosing spondylitis, acute rheumatic carditis, and rheumatoid arthritis (including juvenile forms). Also used for dermatomyositis, polymyositis, and systemic lupus erythematosus.
- Miscellaneous Uses: Tuberculous meningitis, trichinosis with neurological or cardiac involvement, and adrenal function testing.
Mechanism of Action
Injection (IV, IM, or Local Use):
- Emergency IV therapy (e.g., anaphylaxis, severe asthma, cerebral edema): Initial dose of 10–20 mg IV, followed by 6 mg IV or IM every 6 hours until stabilized.
- Intra-articular: 2–4 mg for large joints, 0.8–1 mg for small joints.
- Intrabursal: 2–4 mg; in tendon sheaths: 0.4–1 mg.
- Dilution with Infusion Fluids: Can be diluted with solutions such as 0.9% Sodium Chloride, 5% Glucose, or Ringer’s solution and remains stable for at least 24 hours.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
Endocrine & Metabolic: Cushing-like symptoms, hirsutism, menstrual irregularities, adrenal suppression, impaired glucose tolerance, calcium imbalance.
Fluid & Electrolyte Disturbances: Sodium retention, hypertension, hypokalemia.
Musculoskeletal: Myopathy, osteoporosis, aseptic necrosis.
Gastrointestinal: Peptic ulcers, perforation, gastrointestinal bleeding.
Dermatologic: Delayed wound healing, skin thinning, acne, bruising.
Neurological: Mood swings, insomnia, euphoria, depression, psychotic reactions.
Ophthalmic: Increased intraocular pressure, cataracts.
Immunosuppressive Effects: Higher infection risk, reduced vaccine efficacy
✔️ Dosage & Administration
Dosage varies based on the severity of the condition and patient response. If no improvement is observed within a few days, continued use is not recommended.
Oral Tablets:
- Adults: 1–10 mg per day.
- Children: 0.03–0.20 mg/kg body weight per day.
- Higher doses may be necessary initially, followed by gradual tapering.
- Dexamethasone Suppression Test: 1 mg at 11 PM; plasma cortisol is measured the next morning. If needed, extended testing involves 0.5 mg every 6 hours for 48 hours, followed by 2 mg every 6 hours for another 48 hours.
✔️ Drug Interactions
- Diuretics & Cardiac Glycosides: Risk of enhanced potassium loss, increasing toxicity in patients on cardiac glycosides.
- Antidiabetics: May impair glucose tolerance, necessitating dose adjustments.
- NSAIDs: Increased risk of gastrointestinal ulcers.
- Oral Anticoagulants: May alter their effectiveness.
- Liver Enzyme Inducers (e.g., rifampicin, barbiturates, phenytoin): May reduce dexamethasone effectiveness.
- Salicylates: Caution when reducing steroid doses to prevent salicylate toxicity.
- Antacids (e.g., magnesium trisilicate): May impair steroid absorption; spacing doses is recommended.
✔️ Contraindications
- Active gastric or duodenal ulcers.
- Systemic fungal infections.
- Active viral infections (e.g., varicella, herpes).
- Glaucoma.
- Hypersensitivity to corticosteroids.
✔️ Pregnancy & Lactation
- Category C: Use only if benefits outweigh potential fetal risks.
- Glucocorticoids pass into breast milk; high doses may require discontinuation of breastfeeding.
✔️ Precautions & Warnings
- Use the lowest effective dose.
- Taper doses gradually to prevent adrenal insufficiency.
- Caution in hypertension, heart failure, renal insufficiency, osteoporosis, peptic ulcers, and psychiatric conditions.
- Growth suppression risk in pediatric patients—use a minimal effective dose.
✔️ Storage Conditions:
- Store in a cool, dry place away from light and moisture.
- Keep all medications out of children's reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
